![]() Almost 80% of the experimental animals are rodents that include mice, rats, guinea pigs and others (10% are fish, amphibians, reptiles and birds). An estimation suggests some dozens of millions per year, being 15 million in the United States, 11 million in Europe, five million in Japan, two million in Canada and less than one million in Australia. It is difficult to evaluate the number of animals employed in scientific experiments every year. They are recognized as the preeminent model in numerous fields, including neurobehavioral studies, cancer and toxicology. The laboratory rat is an inevitable part of today's biomedical research. These differences signify the variations in their anatomy, physiology and developmental processes, which must be taken into consideration while analyzing the results or selecting the dose of any research in rats when age is a crucial factor. ![]() Numerous researchers performed experimental investigations in albino rats and estimated, in general, while considering their entire life span, that a human month resembles every-day life of a laboratory rat. In adulthood, every day of the animal is approximately equivalent to 34.8 human days (i.e., one rat month is comparable to three human years). The overall findings indicate that rats grow rapidly during their childhood and become sexually mature at about the sixth week, but attain social maturity 5-6 months later. Thus, the current review attempts to compare rat and human age at different phases of their life. A number of studies have tried to detect these correlations in various ways, But, have not successfully provided any proper association. But, the precise correlation between age of laboratory rats and human is still a subject of debate. By late 18 th or early 19 th century, albino rats became the most commonly used experimental animals in numerous biomedical researches, as they have been recognized as the preeminent model mammalian system.
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